• Technical University Cluj Napoca
  • The“ Ion Chiricuta” Cancer Institute -Comprehensive Cancer Center   
  • University of Medicine and Pharmacy Iuliu Hatieganu Cluj Napoca
  • Software Itc Cluj S.A.

Intelligent System for the Noninvasive Detection and Evaluation of Liver Fibrosis, Restructuration and Dysplastic Nodules, Using 2D/3D Ultrasound and Molecular Markers – SIDEF.

From the informational website about a CEEX research project  SIDEF

The S.I.D.E.F. project wants to create a model for the prediction of the degree of liver damage, based on an intelligent system of noninvasive evaluation and detection of fibrosis, regeneration and dysplastic nodules of the liver with the use of 2D and 3D ultrasonography and molecular markers. In order to do this one would have to perform an experimental research, the result of which will be a prototype able to analyze the ecographic 2D and 3D image and discern between normal and other different pathologic stages (fibrosis, liver cirrhosis or dysplastic nodules). In the second stage, of applicative research, the product will be developed and optimized through clinical correlation studies, through the integration of the information provided by different molecular markers, so in the end one could homologate and validate a noninvasive diagnosis computer system of liver diseases. The automatic analysis system of the ecographic images is desired to also have a knowledge communication and managing role, helping the doctor to take optimal diagnosis decisions (C.A.S. – Computer Aided Solution).

The consortium– made of five institutions with tradition in research and with experience in excellence research – wants the long term results of the project to allow a better understanding of the pathogenetic mechanisms that cause the ecographic perceptible changes. The creation of some recommendations of treatment based on complex, but noninvasive, evaluation in liver disease will constitute the crowning of all efforts made by researchers. Another important aspect is that of the possible advantage offered by the “export” model to other fields where it could be applied.

The degree of innovation and originality of the project is based on the integration in medical practice of a diagnosis computer aided system, which will realize the integrated processing of complex medical data, allowing the noninvasive hi-fi diagnosis of liver disease. We consider that this model is a “virtual liver biopsy”. This could help the original research contribution, in a field of high interest in the European research circuit, permitting the connection between the scientific and academic community in Romania and the international idea flow in the field of hepatology. The complexity of this project is the result of the great work volume, condensed with the help of modern computer techniques, of the information processing speed and of the significant decrease of diagnosis costs. By abandoning the invasive diagnosis, as much as it is possible, one could achieve a substantial saving of founds and a shifting of financial resources from the diagnostic needs to the therapy.

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